ISSN Print 2713-0894    ISSN Online 2713-0908
BIOMEDICAL JOURNAL OF ERMC EASTERN EUROPEAN

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The article provides a comparative analysis of the Orthodox ethics of the Russian religious philosopher Vladimir Solovyov and the mystical ethics of the Renaissance representative Dante Alighieri. The aim of the study is to identify points of contact between the ethical concepts of these two very different philosophers. Two works were selected for comparison: “Readings on God-Manhood” by V. S. Solovyov and “The Divine Comedy” by Dante. The ethics of man’s abstraction from natural principles and the acquisition of a metaphysical existence by the individual are explored. Three stages of human ethical development are considered in the concept of V. S. Solovyov. It is shown that in the process of ethical development, the human personality perceives the Divine principle and reunites nature with it. It is noted that for Solovyov, ethical development is a positive and objective process — a divine-human process. A significant place is devoted to the symbolic-metaphysical understanding of ethics in Dante Alighieri’s Divine Comedy. It is indicated that Dante shows an inexhaustible source of possibilities for man to overcome the burden of earthly existence and turn to the true ethics of divine revelation. It is concluded that both Dante Alighieri and V. S. Soloviev came to the realization that the religious principle in man is the only real implementation of the free ethical process.
VIEWS 47
A patient-physician relationship is regulated by the principles of medical ethics and the Law on Healthcare of the Russian Federation. In pediatric practice, ethical issues are even more important. Pediatric otorhinolaryngology is one of the most popular branches of medicine that diagnoses, treats and prevents diseases of the ear, throat and nose (ENT) in children. ENT diseases are most common in childhood. Pathology of the upper respiratory tract and diseases of the ear and mastoid process account for about 20% of all cases. The prevalence of pediatric otorhinolaryngologic diseases currently accounts for 184 per 1,000 children; however, as they age, the chronic pathology of the ear, throat and nose is increasing. This field has its own unique ethical and legal aspects that require special attention of medical professionals, parents, and legislators. In Russia, ethical and legal issues of pediatric otorhinolaryngology have not been addressed for a long period of time, although it has its own peculiarities due to anatomical and physiological features of a child’s ENT organs. The article provides detailed description of ethical and legal problems in the practice of an otorhinolaryngologist and describes how to solve them. Compliance with the rules will improve quality of medical aid among children.
VIEWS 126

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Treatment of rheumatoid arthritis is a complex and time-consuming process that does not always lead to significant results both due to poor effectiveness of drugs and drug toxicity. It means we need to search for new pharmacological targets to influence the pathological process, one of which is inhibition of proteinase-activated receptors 2 (PAR2 receptors) activity. In 2016–2019, synthesis of low-molecular-weight antagonists of PAR2 receptors belonging to 4,5-dihydroisoxazole-5-carboxamide derivatives was carried out, and in 2023 their anti-inflammatory efficacy was examined using the formaldehyde edema model. The most effective laboratory R004 compound was tested on a model of autoimmune pristane-induced inflammation in rats. During treatment of chronic inflammation in rats, R004 inhibited significant development of edema of feet, damage to small joints, and specific changes in the formula of white blood, and according to biochemical blood test led to normalization of liver and kidney functions and energy metabolism. R004 turned out to be more effective and safer than the comparator drugs such as diclofenac sodium and dexamethasone.
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