Medical Ethics

ISSN Print 2713-0894 ISSN Online 2713-0908

BIOMEDICAL JOURNAL OF ERMC EASTERN EUROPEAN

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Issue 3, 2025

Topic Space biology, space medicine and space psychologyin the context of "human sciences"

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Issue 2, 2024

Topic Ethical aspects of creating clinical guidelines for practitioners

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Issue 3, 2024

Topic Application of artificial intelligence in healthcare: ethical conclusion

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Issue 4, 2024

Topic Implementation of neurotechnologies. Development of ethical guidelines

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Issue 1, 2025

Topic Amendments and additions to the Helsinki Declaration of the World Medical Association "Ethical principles for medical research involving human subjects"

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Issue 2, 2025

Topic Bioethical problems of quantum computing

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New articles

Yaichkov II, Volkhin NN, Petukhov SS, Lasaryanz OE

4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide (ODASA), which is a novel selective type II carbonic anhydrase inhibitor for treating open-angle glaucoma, is undergoing preclinical testing. Pharmacokinetics of the substance have only been studied in rats. Prior to clinical studies, it is necessary to assess the systemic exposure of ODASA in non-rodents. ODASA was administered to Soviet Chinchilla rabbits at a dose of 0.28 mg/kg. About 40 µl of ocular suspension of ODASA was instilled into each eye of animals from the first group, whereas the second group received intraperitoneal injections of the investigational drug. Each group consisted of 6 male rabbits. Samples were obtained prior to administration of ODASA and during 288 hours following the administration at 16 time points. A 10% ascorbic acid solution was added to plasma before freezing. The samples were analyzed using HPLC-MS/MS. Following eyedrop instillation, relative bioavailability for ODASA was 31% as compared to IP administration. Thus, as ODASA was well absorbed into the systemic circulation of rabbits following topical eyedrop instillation, testing its pharmacokinetics in healthy volunteers will be obligatory if the preparation proceeds to phase 1 of clinical studies.

Received: 2025-07-23

Published online: 2025-11-09

DOI: 10.24075/medet.2025.020

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VIEWS 27

Kostrov SA, Potapov MP

The article presents a review on the potential of the distributed ledger technology (DLT), particularly federated blockchain, that can be used to create a secure, transparent and patient-managed ecosystem of medical data. The hybrid architecture reviewed uses the blockchain to store immutable metadata and hashes, and manage large amounts of data (for example, diagnostic images) on external cloud storage, which ensures the integrity of data without network overloading. The key aspect of the research is to analyze long-term threats posed by quantum computing that makes current cryptographic standards vulnerable. It is stressed that adoption of post-quantum cryptography (PQC) is required to ensure future security of medical data. An analysis was carried out to compare the leading global (CRYSTALS-Dilithium, Falcon) and Russian (Hypericum, Shipovnik) post-quantum cryptography algorithms.

Received: 2025-08-13

Published online: 2025-11-03

DOI: 10.24075/medet.2025.019

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VIEWS 42

Chelnokova OG, Khokholov AL, Mozzhukhina LI, Salova AL

In latent tuberculosis infection (LTBI), there are no clinical or radiographic symptoms of active tuberculosis (TB), although immunological tests are positive. Meanwhile, the risk of progression from LTBI to active TB remains high, especially in children. It is estimated that a quarter of the world’s population has LTBI. Identifying LTBI as a predictor of active TB represents a major public health achievement, as preventive activities can help stop the spread of TB in many cases. Phthisiologists specialize in the diagnosis, monitoring, and treatment of children with LTBI. Because the process is prolonged, pediatricians actively monitor and care for somatic issues in children with LTBI. During examination and treatment, both doctors and patients — together with their parents — may encounter numerous ethically challenging situations that significantly affect the quality of medical care and treatment outcomes for children with LTBI.

Received: 2025-06-10

Published online: 2025-10-08

DOI: 10.24075/medet.2025.018

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VIEWS 194

Sokolova OV, Smirnova AV, Isaeva IYu, Alekseeva KS

In this article, the issues of digital literacy that arise during communication of medical and pharmaceutical workers have been reviewed. The right for digital literacy, access to education that improves comprehension and develops digital skills while using medical information systems relates to one of the issues. The goal of the research is to assess digital literacy of healthcare professionals, which is essential for professional interaction during clinical research. Applicable laws and scientific publications regulating healthcare digitalization were used as instructional material. Circulation of medicinal preparations used in clinical research was examined through summary reports of medical companies in 2022–2024. Data from registered databases served as a basis for sociological research to determine digital literacy of professionals. According to the survey results, over 90.0% of respondents have computer-assisted workplaces, about 50.0% of them assessed their level of digital competence as average, and 67.4% need to improve their digital literacy. Optimal organizational solutions allow to improve digital literacy of all healthcare professionals producing a positive effect on ethics of professional interaction.

Received: 2025-09-09

Published online: 2025-09-29

DOI: 10.24075/medet.2025.017

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VIEWS 193

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Popular articles

Pleshchev IE, Shishkin AA, Ivashkovskaya AV

The purpose of this study is to examine the existing ethical standards and guidelines to provide a comprehensive overview of ethical issues and processes related to research and publications in domestic and international medical practice. The importance of informed consent, data integrity, plagiarism, authorship disputes, and conflicts of interest are just some of the key topics briefly covered in the article. It is obvious that ethical standards and regulations in medical (clinical) research are crucial for determining how research is conducted and how scientific articles are published.

Received: 2025-04-30

Published online: 2025-05-30

DOI: 10.24075/medet.2025.004

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VIEWS 633

The field of medicine has traditionally focused on such symptoms of a disease as pain, inflammation, and tissue deformity. However, according to the modern approach, it is necessary to identify the cause of the disease, which is often hidden deep inside the body. Examining genetic polymorphism as the basis for purulent complications after treatment of the lower limb injury was one of the method that could solve the problem. Epidemiological observations confirm that purulent complications after orthopedic surgery are associated with hereditary predisposition factors. This highlights the important role of genetic changes in development and course of this pathology. However, any medical intervention is associated with potential risks, including emotional pain of the patient, violation of personal data confidentiality and misuse of the obtained information. That is why it is important to think in advance about the possible consequences of genetic tests and to find ways how to resolve ethical issues.

Received: 2025-04-30

Published online: 2025-05-25

DOI: 10.24075/medet.2025.003

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VIEWS 584