2024 / 01

Next Paper
DOI: 10.24075/medet.2023.034

ORIGINAL RESEARCH

Ethical aspects, safety issues of cardiac surgery and prediction of adverse events

Shereshneva MV1, Ilyin MV1,2
About authors

1 Regional Clinical Hospital, Yaroslavl, Russia

2 Yaroslavl State Medical University, Yaroslavl, Russia

Correspondence should be addressed: Marina V. Shereshneva
Revolutsionnaya Str., bld. 5, Yaroslavl 150000, Russia; ur.xednay@avenhserehs.m

About paper

Author contribution: Shereshneva MV - review of actual Russian and foreign literature related to the examined issue, identification of the study subject, determination of the goal and objectives, laboratory examination of induced blood oxidation values, mathematical and statistical data processing, making conclusions; Ilyin MV - development of study program, formulation of the study subject, determination of goal and objectives, mathematical and statistical data processing, making conclusions.

Compliance with ethical standards: the study underwent ethical expertise and was approved by the Ethics Committee of the Yaroslavl State Medical University of the Ministry of Health of Russia. Prior to inclusion, the patients were explained the study goals and objectives in detail, and a voluntary informed consent was obtained.

Received: 2023-11-26 Accepted: 2024-01-21 Published online: 2024-02-28
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In cardiac surgery, patient’s awareness and consent to surgery are problematic as due to the lack of previous medical background a patient can’t understand the processes occurring in the body and effects of exposure on them. Thus, provision of sufficient information by a doctor is a part of safe surgical strategy. An open randomized prospective trial involving 89 patients with stable coronary artery disease (CAD) was conducted. High rate of blood oxidation is believed to be an independent predictor of cognitive dysfunction development during the early postoperative period of coronary artery bypass grafting (CABG). Determination of blood oxidation rate is a tool of risk management during cardiac surgery starting from the stage of preoperative preparation, which is optimal to implement a safe strategy, including psychological and drug-induced support of the patient aimed at prevention of cognitive disturbances.

Keywords: oxidative stress, safety, coronary artery disease, cardiac surgery

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