The article reviews the edition known as ‘Ethical Examination in Biomedical Research: Practical Considerations’ (third edition, revised and enlarged) under the general editorship of Professor Khokhlov AL, a corresponding member of the Russian Academy of Sciences. Due to a constantly growing number of clinical trials of medicinal products and improved level and quality of medical technologies, the role of an ethical examination aimed at compliance with ethical rights of trial participants and consumers, and safety aspects is increased. The article sums up what was described in the published edition.