The article is devoted to the role of humanitarian education in medical universities of Russia. Events of recent years (lack of attention to the value orientation of students and, as a consequence, leaving the profession or feeling unsatisfied with it) that occurred in Russian healthcare determined the interest in this issue. The research data were obtained using the systemic approach. Owing to this, medical education was viewed as a non-integrated set of scientific, clinical proper and humanitarian knowledge and assessments. In this respect, the perspective of using humanitarian expertise of academic courses has been discussed. This was done to coordinate the efforts of socialization agents in development of professional orientation among medical students. A comparative analysis of the effect of High-Hume technologies and mentorship on the positive solution of this problem has been performed. A conclusion about the use of the complementary principle while implementing High-Hume and mentorship has been made. Search for the aggregator of integrative processes in medical and humanitarian preparation enabled to conclude that bioethics is a system-forming factor of developing professional orientation in medical education. Recommendations on the use of scientific and organizational achievements in bioethics in the practice of medical education have been developed.