Liver and kidney transplantation is the most effective and frequently the only radical method of treatment of patients with end-stage chronic kidney/liver diseases. Expenditure on transplantation is rather high. A number of patients with a reduced function of kidneys or liver is increasing rapidly. Thus, the problem is pressing and interdisciplinary. It has serious social and economic consequences for the Russian Federation. In this respect, analysis of the structure of use of medicinal preparations (MPs) enables to rationalize their application in clinical practice. This allows to carry out targeted measures to improve costly drug-induced therapy. Having analyzed prescriptions, it has been found out that MPs related to 52 pharmacotherapeutic groups were used in pharmacotherapy during kidney and liver transplantation within the analyzed period. ABC analysis revealed preparations included into group A, a group of immunosuppressants with the largest costs.