Author contribution: Kubar OI — Historical and archival study and review of the formation and development of research ethics in Russia; analysis of the specifics of informed consent in vaccine research and development of an ethical algorithm for the control of emergency epidemic situations. Bichurina MA, Romanenkova NI — carrying out a complex of virological and epidemiological studies in the format of the WHO Subnational Laboratory for the Elimination of Preventable Infections.