The article deals with aspects of legal regulation of human (somatic, germline, heritable) gene editing techniques. Principal risks and problems of implementing these techniques in clinical practice are mentioned. The experience of using the techniques of genome editing and recommendations of WHO 2022 are analyzed. Special attention is paid to conflicts of interests and conflicts of liabilities while creating the concept of legal regulation of genome editing in humans. The conclusions are drawn concerning the necessary disclosure of data about the conducted research and results obtained globally to create the principles and standards of legal regulation of genome editing in humans. In spite of the existing controversies between the scientific communities and countries, it is extremely important to promote an international dialogue, as human genome editing concerns everyone and future generations, variety of human community and safe life and health.