A half a century ago Archibald Cochrane, British physician and researcher, emphasized the necessity for critical assessment and a more elaborated approach to biomedical research results. Evidence-based medicine, which is designed to protect a patient from using scientifically unjustified technologies in healthcare, was widely developed subsequently. However, it soon became evident that numerous essential scientific researches contain a substantial proportion of costly but less informative and unjustified trials. They do not add any significant knowledge (wastes or unnecessary spending in research). In 2014, like-minded investigators have joined together in the international community of Evidence-based research. They suggested a plan of actions and algorithm for evidence-based research denoting the liability of all subjects. It is essential that the processes were under supervision of the scientific and medical society.