2023 / 01

DOI: 10.24075/medet.2023.008

REVIEW

The ethics of deprescribing in older adults

Zyryanov SK, Baibulatova EA
About authors

Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia

Correspondence should be addressed: Elena A. Baibulatova
ul. Miklukho-Maklaya, 6, Moscow, 117198, Russia; ur.ndur@ae-avotalubyab

About paper

Author contribution: Zyryanov SK — article designing, scientific counselling, literature counselling; Baibulatova EA — review of article-related publications, writing an abstract, writing an article.

Received: 2023-02-02 Accepted: 2023-03-05 Published online: 2023-03-13
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  1. Gnjidic D, Hilmer SN, Blyth FM, et al. Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol. 2012; 65 (9): 989–95.
  2. Kantor ED, Rehm CD, Haas JS, et al. Trends in prescription drug use among adults in the United States from 1999–2012. JAMA. 2015; 314(17): 1818–31.
  3. Bradley MC, Motterlini N, Padmanabhan S, et al. Potentially inappropriate prescribing among older people in the United Kingdom. BMC Geriatr. 2014; 14: 72.
  4. Todd A, Jansen J, Colvin J, McLachlan AJ. The deprescribing rainbow: a conceptual framework highlighting the importance of patient context when stopping medication in older people. BMC Geriatr. 2018 Nov 29; 18 (1): 295. DOI: 10.1186/ s12877-018-0978-x. PMID: 30497404; PMCID: PMC6267905.
  5. Woodward M. C. Deprescribing: achieving better health outcomes for older people through reducing medications. J Pharm Pract. Res. 2003; 33: 323–328.
  6. Reeve E, Gnjidic D, Long J, Hilmer S. A systematic review of the emerging definition of “deprescribing” with network analysis: implications for future research and clinical practice. Br J Clin Pharmacol. 2015; 80: 1254–1268.
  7. Hanlon JT, Schmader KE. The Medication Appropriateness Index at 20: where it started, where it has been, and where it may be going. Drugs Aging. 2013; 30: 893–900.
  8. Wallace E, McDowell R, Bennett K, Fahey T, Smith SM. Impact of potentially inappropriate prescribing on adverse drug events, health related quality of life and emergency hospital attendance health related quality of life and emergency hospital attendance in older people attending general practice: a prospective cohort study. J Gerontol. Ser. A Biol Sci Med Sci. 2016. Available from URL: https://doi.org/10.1093/gerona/glw140.
  9. Maher RL, Hanlon J, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf. 2014; 13: 57–65.
  10. Passarelli MCG, Jacob-Filho W, Figueras A. Adverse drug reactions in an elderly hospitalised population: inappropriate prescription is a leading cause. Drugs Aging. 2005; 22: 767–777.
  11. Reeve E, Shakib S, Hendrix I, et al. The benefits and harms of deprescribing. Med J Aust. 2014; 201 (7): 386–389.
  12. Reeve E, Denig P, Hilmer SN et al. The Ethics of Deprescribing in Older Adults. Bioethical Inquiry 13, 581–590 (2016). Available from URL: https://doi.org/10.1007/s11673-016-9736-y.
  13. Reeve E, Low LF, Hilmer SN. Beliefs and attitudes of older adults and carers about deprescribing of medications: a qualitative focus group study. Br J Gen Pract. 2016 Aug; 66 (649): e552–60. doi: 10.3399/bjgp16X685669. Epub 2016 Jun 6. PMID: 27266865; PMCID: PMC4979944.
  14. Royal Pharmaceutical Society. Medicines optimisation: helping patients to make the most of their medicines. London: Royal Pharmaceutical Society; 2013. Available from URL: http://www.rpharms.com/promoting-pharmacy-pdfs/helping-patients-make-the-most-of-their-medicines.pdf (accessed 24 May 2016).
  15. Stiggelbout AM, Van der Weijden T, De Wit M, et al. Shared decision making: really putting patients at the centre of healthcare. BMJ. 2012; 344: e256.