REVIEW

Ethical issues of pharmacotherapy and clinical trials in patients with dementia

Kazakov AS, Zyryanov SK
About authors

Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia

Correspondence should be addressed: Sergey K. Zyryanov
ul. Miklukho-Maklaya, 6, Moscow, 117198, Russia; ytisrevinu.ndur@ks_vonayryz

About paper

Author contribution: Zyryanov SK — article designing, scientific counselling, literature counselling; Kazakov AS — review of article-related publications, writing an abstract, writing an article.

Received: 2023-04-17 Accepted: 2023-05-20 Published online: 2023-05-18
|
  1. Sperling RA, et al. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & Dementia. 2011; 7: 280–292.
  2. Dubois B, et al. Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria. Lancet Neurology. 2014; 13: 614–629.
  3. Peter KR, Lynn Beattie B, Feldman HH and Illes J. A conceptual framework and ethics analysis for prevention trials of Alzheimer Disease. Progress in Neurobiology. 2013; 110: 114–123.
  4. Sperling RA, Karlawish J and Johnson KA. Preclinical Alzheimer’s disease — the challenges ahead. Nature Reviews Neurology. 2013; 9: 54–58.
  5. Sperling RA, et al. The A4 study: stopping AD before symptoms begin? Science Translational Medicine. 2014; 6: 228fs13.
  6. Emanuel EJ, Wendler D and Grady C. What makes clinical research ethical? JAMA. 2000; 283: 2701–2711.
  7. Appelbaum PS and Roth LH. Competency to consent to research: a psychiatric overview. Archives of General Psychiatry. 1982; 39: 951–958.
  8. Karlawish JHT, Casarett DJ and James BD. Alzheimer’s disease patients’ and caregivers’ capacity, competency, and reasons to enroll in an early-phase Alzheimer’s disease clinical trial. Journal of the American Geriatrics Society. 2002; 50: 2019–2024.
  9. Kim SYH. Improving medical decisions for incapacitated persons: does focusing on ‘accurate predictions’ lead to an inaccurate picture? Journal of Medicine and Philosophy. 2014; 39: 187–195.
  10. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s Dement. 2011 May; 7(3): 270–279.
  11. Gaster B, et al. Advance directives for dementia: meeting a unique challenge. JAMA. 2017; 318(22): 2175–6.
  12. Cantor NL. On avoiding deep dementia. Hastings Center Report. 2018; 48(4): 15–24.
  13. Dresser R. Advance directives and discrimination against people with dementia. Hastings Center Report. 2018; 48(4): 26–7.