An increased number of patients who have tuberculosis (TB) comorbidity with cancer leads to a number of ethical problems. Approaches to treatment of oncological diseases in patients with TB have not been developed yet limiting provision of care to patients with comorbidities. The priority of TB treatment leads to a loss of time spent on treatment of oncological diseases and occurrence of vicious circles when progression of an oncological disease prevents from an effective treatment of TB and initiation of cancer treatment. At the same time, interaction of anti-tuberculosis and antitumor drugs has not been studied, limiting their simultaneous administration. Long-term diagnostics of TB represents an ethical problem. The set problems can be solved during scientific research on TB prevention in cancer patients, treatment of patients with comorbidities and interdisciplinary interaction in practical healthcare on an individual basis.