Acknowledgements: the authors express their deep gratitude to Elena A. Volskaya, Candidate of Historical Sciences, Advisor to Director of N. A. Semashko National Research Institute of Public Health, Chairman of the Independent Interdisciplinary Committee for the Ethical Review of Clinical Trials, and Chairman of the Interuniversity Ethics Committee for supporting the idea of the article and advising on ethics issues.

Author contribution: Semenova NV — the idea of the article, problem statement, discussion of key substantive and ethical issues, planning and discussion of the article, editing the text of the article, its design; Martynyuk KL — participation in the discussion of the problem, study of world experience and literature on the topic, systematization and generalization of data, participation in discussion of the results, and writing the main text of the article.

Compliance with ethical standards: the ethics committee meeting was not held as the material for publication included theoretical provisions without involvement of patients; the article was prepared in compliance with ethical standards.