Author contribution: Chelnokova OG — consultations with patients, study of related literature, systematization and generalization of data, participation in the discussion of the results, writing and formatting of the article; Khokhlov AL — problem statement, discussion of key ethical issues, planning and discussion of the article; Mozzhukhina LI — studying the literature on the topic, participating in the discussion of the results and writing an article; Salova AL — consultations with patients, study of related literature, participation in the discussion of patients and results, writing an article.

Compliance with ethical standards: the meeting of the ethics committee was not held because it is experience of ethically observing patients in real clinical practice that has been discussed.