Author contribution: Olga I. Kubar – examination of archives and historical documents to analyze the formation and development of research ethics in Russia; comparison of historical documents of Russia related to informing patients about a modern standard of ethical regulation, ethical commentary on the trial of former soldiers of the Japanese army accused of manufacturing and use of bacteriological weapon in the city of Khabarovsk in 1949. The value of prohibition ethical inevitability is evaluated to protect future generations.