The legislation of the Russian Federation in the area of regulation of a pharmaceutical activity has undergone changes aimed at provision of pharmacies with professionals having modern skills of effective professional interaction. Objective of the study was to examine the structure of professional flexibility and procedure of its formation. A sample consisting of 345 pharmaceutical workers including 283 chemists (82%) and 62 pharmacists (18%) was formed to implement the method of empirical research of professional flexibility. The method included diagnostic tools to examine the elements of professional flexibility. Pharmaceutical professionals who performed an effective professional interaction have a sufficient level of professional flexibility. The structure of professional flexibility was studied. It consists of cognitive, motivational value, socio-communicative, and reflective elements. The elements of professional flexibility were estimated using the diagnostic tools. The study results showed that it was necessary to form professional flexibility among pharmaceutical specialists. A set of academic disciplines embracing various levels of professional education was developed by us to reach the purpose. Depending on the level of professional education, the objective of disciplines and cycles was either to form the basis of professional flexibility, or shape its certain level.